The Cunningham Panel Test

The Cunningham Panel Test

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The Cunningham Panel measures the level of autoantibodies associated with certain neuropsychiatric illnesses and the capability of these autoantibodies to cause neurologic and psychiatric symptoms. Each individual test result can aid your clinical diagnosis and support an appropriate treatment plan for your patient(s).

The Cunningham Panel Test in Hendersonville NC

In our patients, we have found that elevated anti-D1 antibodies have been associated with psychiatric symptoms, mood swings, depression, anxiety, irritability, aggression, and in some cases, delusions, and/or psychosis (internally referred to as the psychiatric band).

In our patients, we have found that elevated anti-D2L antibodies have been associated with movement disorders and chorea or choreiform movements. Some patients with a previous diagnosis of ADHD (because they were unable to hold still) or exhibit an increase in hyperactivity are likely to show an elevation in D2L. Parkinsonian tremors and movement issues tend to be associated with elevated D2L and/or Myoclonus (quick involuntary muscle jerks) also may be seen. (Internally referred to as the movement band).

In our patients, we have found that elevated anti-Lysoganglioside GM1 antibodies tends to be associated with tics, and frequently, complaints of joint/connective tissue pain. There is emerging evidence that Lyme disease patients are more likely to have an elevation in Lyso GM1. (Internally referred to as the tic band).

In our patients, we have found that elevated anti-Tubulin antibodieshave been associated with obsessions and compulsions, and cognitive impairment. Patients with elevations in anti-tubulin antibodies frequently report experiencing "brain fog" and difficulty with focus and attention. (Internally referred to as the OCD band).

In our patients, we have found that elevated CaM Kinase II activity has been associated with sympathetic nervous system activation including fight or flight behavior, separation anxiety, urinary problems, bedwetting, sensory sensitivities. When elevated, we have also found it to be associated with active infection(s) of some type. Circulating autoantibodies increase CaMKII activity, which then causes an increase in the production of dopamine, epinephrine and norepinephrine. When one or more antibody titers on the panel is elevated, a CaMKII result at or below the normal level may indicate a shift from a cytokine-driven condition to a purely autoimmune status. It has been reported that antimicrobials may still be helpful, but immune modulation of some kind may be necessary.

To get the Cunningham Panel Test in Hendersonville, call our team at Sage Wellness Group today!


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It is best to call to make an appointment with a specific provider.

Sage Wellness Group
1509C Haywood Rd
Hendersonville, NC 28791
(828) 696-8900